There are other posts about this, but for you in particular, probably not. Tell us more about yourself and you will get more ideas. So far, we know you as Illini. What is your career, hobbies, something fun to do?
My last personalized plate was 4RE308. Needless to say, this was on the third car from the left, below. Ah, to be young (and a whole bunch less poor) again.
Since then I've pretty much abandoned the idea of vanity plates in favor of relative anonymity. If you've had a bad day and do something monstrously stupid while driving it tends to reduce the "I remember you..." problem.